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Papers & Patents

 

Working regularly in highly scientific fields and developing innovative solutions in the areas diagnostic tools, (human and veterinary) dietary food supplements, cosmetics  lead to a series of publications and patents for SCIOTEC:

 

 

Latest Patents

  • Verfahren zur Bestimmung von Atrialem Natriuretschem Peptid
  • WO 00/19207
    Biomedica GmbH: W. Woloszczuk, A. Missbichler
  • Verfahren zur Bestimmung der biologisch wirksamen Parathormon-Aktivität in einer Probe
    WO 01/44818 A2
    Immundiagnostik: FP Armbruster, A Missbichler, H Schmidt-Gayk, HJ Roth
  • Verfahren zur Bestimmung der Aktivität von Diaminooxidase
    AT 411688
    Jarisch R, Missbichler A, Reichl H
  • Verfahren zur Detektion von membrangebundenen und/oder amyloidogenen Proteinen
    A-1765/2002
    Missbichler A, Reichl H
  • Diaminooxidase-hältige Zusammensetzung oral
    AT 502098; EP1763363
    Missbichler A, Reichl H, Gabor F
  • Enzymaktivitäts-Steigerung kosmetisch
    Nr 503070;
    Missbichler A, Reichl H, Gabor F
  • Verfahren zur Bestimmung von Diaminooxidase
    Nr. 502850;  EP 1948819
    Missbichler A, Mayer I
  • Treatment of Fructose Malabsorption
    A1380/2008
    A.Missbichler

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Papers in Peer-Reviewed Journals:

  • Hinterstoisser B., Missbichler A., Pineau B., Peschek G.A.: Detection of chlorophyllide in chlorophyll-free plasma membrane preparations from anacystis nidulans in BBRC 154/3 pp 839-846 (1988)
  • Peschek G.A., Hinterstoisser B., Wastyn M., Kuntner O., Pineau B., Missbichler A., Lang J.: Chlorophyll precursors in the plasma membrane of a cyanobacterium, anacystis nidulans in J. Biol. Chem. 264/20 pp 11827-11832 (1989)
  • Peschek G.A., Hinterstoisser B., Pineau B., Missbichler A.: Light dependent NADPH-protochlorophyllide oxireductase activity in purified plasam membrane from the cyanobacterium anacystis nidulans in BBRC 162/1  pp 71-78 (1989)
  • Missbichler A., Hartter E., Woloszczuk W., Pittner F.: Determination of à-human atrial natriuretic peptide in urine using combination of HPLC with RIA strongly indicates non-immunoreactive metabolites in J. Biochem and Biophys Methods 20, pp 113-121 (1990)
  • Missbichler, A., Ferris, R., Hartter, E: Immobilization of human atrial natriuretic peptide on insoluble supports and affinity purification of specific antibodies from a polyclonal goat anti ANP serum in J. of Chromatography 510, pp 339-346 (1990)
  • M. Schuller, R.Stetter, S. Skrabal, A. Missbichler, E.Hartter und W.Woloszczuk: Radioimmunoassay of C-terminal Big Endothelin(22-38). In: Eur. J. Clin. Chem. Clin Biochem (1991) Vol 29, pp 147-150
  • Tampe J., Broszio P., Mannek H., Missbichler A., Blind B., Mueller K., Schmidt-Gaygk H., Armbruster, F.P: Charakterisation of Antibodies against  Human N-terminal Parathyroid Hormone by Epitope Mapping  in Journal of Immunoassay 13/1, pp 1-13 (1992)
  • M. Heins, H.Stiegler, Y. Fischer, M. Leschke, F.P. Armbruster, A. Missbichler, H. Reinauer: Comparison and Clinical Evaluation if Immunoractive Endothelin, Big Endothelin and C-terminal Big Endothelin. In: Eur J Lab Med, Vol 6, No2, 1998
  • M. Franz, A. Missbichler, W. Woloszczuk: Imunoassays for fragments of human proatrial natriuretic peptides
    WiKliWo 4 /110 (1998)
  • A. Missbichler, G. Hawa, W. Woloszczuk, N. Schmal, E. Hartter: Enzymeimmunoassays für proBNP Fragmente (8-29) und (32-57). J. Lab. Med  1999, 23(4), pp 241-244
  • M. Meyer, FP Armbruster, I. Maier, J. Schwing, C. Haller, A. Missbichler, K. Adermann, WG Forssmann, W. Woloszczuk: Uninary and plasma urodilatin measured by a direct RIA using a highly specific antiserum. Clin Chem 44:12 (1998) pp 2524-2529
  • E. Hartter, S. Khalavpour, A. Missbichler, W. Woloszczuk: Enzyme Immunoassays for fragments (epitopes) of human proatrial natriuretic peptide. Clin Chem Lab Med 2000, 38(1): 27-32
  • A. Gruber, K. Roessler, A. Georgopoulos, A. Missbichler, G. Pavinski, B. Richling: Evaluation of serum and vetricular cerebrospinal fluid endothelin concentrations after early surgical and endovascular treatment of ruptured intracranical aneurysms. Neurosurg Focus 8 (5); 2000
  • A. Missbichler, P.M. Abuja, F. Tatzber, E.Schmiedl, W. Wonisch, U. Resch, E. Ogris, H. Esterbauer: Cu++ mediated LDL Oxidation generates epitopes, which are recognised by human IgG molecules in vitro. In: Biofactors, submitted
  • F. Tatzber, W. Strohmaier, E. Schmiedl, W. Wonisch, A, Missbichler, H. Esterbauer, G. Schlag: Antibodies to oxidised LDL (oLAB) in animals. In: Biofactors, submitted
  • Missbichler A.; Hawa Gerhard; Schmal N.; Woloszczuk W: Sandwich ELISA for proANP 1-98 Facilitates Investigation of Left Ventricular Dysfunction in Eur J Med Res 2001 Mar 26;6(3):105-111
  • Ferris R., Missbichler A., Hartter E., Buxbaum E., Schalkhammer T., Urban G., Pittner F.: Construction and use of two α-human atrial natriuretic peptide fragment affinity chromatography columns in the isolation of C- and N-terminal epitope specific antibodies for use in a prototype à-hANP-Biosensor in: Journal of Chromatography 577, pp 251-256 (1992)
  • Th. Kraus, M. Schuller, F. Klee, M. Bredt, A. Mehrabi, E. Hartter, A. Missbichler, G. Otto : Comparison of biliary ET concentration in liver transplant recipients with values obtained during cholecystectomy. Transpl Int 1996;9 Suppl 1:S135-9
  • I. Mayer, A. Missbichler , F. Wantke , M. Focke , H. Reichl , M. Winter R. Jarisch: Radioextraktionsassay zur quantitativen Bestimmung der Aktivität von Diaminooxidase (DAO) in humanem Serum Allergologie 2005; 1; pp 1-8
  • I. Mayer, F.Pittner, M. Hermann, A. Missbichler: Highly Sensitive Determination of DAO Activity by Oxidation of a Luminescent Reagent Appl Biochem Biotechnol 2007; 143: 164-175   

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Book chapters; Periodicals:

  • R. Jarisch, M. Götz, W. Hemmer, A.Missbichler, M. Raithel, F.Wantke: „Histamin-Intoleranz; Histamin und Seekrankheit” Thieme Verlag (2004), ISBN 3-13-105382-8
  • G. Abbot, C. Lieners, I. Mayer, A. Missbichler, M. Pfisterer, H.Schmutz: „Nahrungsmittelunverträglichkeit (Histamin-Intoleranz)“ HSC-Verlag (2006), ISBN 978-3-9502287-0-0
  • G. Abbot, C. Lieners, I. Mayer, A. Missbichler, M. Pfisterer, H.Schmutz: „Food Intolerance (Histamine-Intolerance)“ HSC-Verlag (2007), ISBN 978-3-9502287-1-7
  • A. Missbichler, M. Pfisterer: „Histamin-Intoleranz erkennen und behandeln“ Österr. Apotheker Zeitung 2007 (17) 822 – 824
  • A. Missbichler, M. Pfisterer: „Biogene Amine und Histamin – Genuss oder Verduss?“ Ernährung Aktuell 2007 (3), 6-9
  • M.Pfisterer,  A.Missbichler „Histaminintoleranz : Ein Chamäleon unter den Nahrugnsmittelintoleranzen – Neue Möglichkeiten der Diagnostik und Therapie“  AZN 02/2008 p24-28
  • A. Missbichler, M. Pfisterer: „Fructose und Histamin“ OM&Ernährung 2008; 124,  p P4-P6
  • A. Missbichler, M. Pfisterer: „Physiologische Grundlagen von Nahrungsmittel-Intoleranzen“ OM&Ernährung 2009; 127,  p F2-F6

Oral and poster PRESENTATIONS, INVITED LECTURES:

  • A. Missbichler, F. Pittner, W. Woloszczuk, E. Hartter:
    Untersuchungen zur Wertigkeit der Bestimmung von humanem atrialen natriuretischem Peptid (hANP) im Harn. Jahrestagung ÖBG & ÖGAI 1987 (Abstract)
  • A. Missbichler, E. Hartter, W. Woloszczuk, F. Pittner:
    Direkter quantitativer Nachweis von humanem atrialem natriuretischem Peptid (hANP) im Harn mittels HPLC. In: Hoppe-Seyler 369 (1988) p878 (Abstract)
  • Peschek G.A., Hinterstoisser B., Pineau B., Missbichler A.:
    Chlorophyll A biosynthesis in Cyanobacteria: Occurrence protochlorophyllide and chlorophyllide in chlorophyll-free plasma membrane preparations of Anacystis Nidulans. In: Hoppe-Seyler 369 (1988) p890 (Abstract)
  • A. Missbichler, R. Ferris, E. Hartter, W. Woloszczuk, F. Pittner: The use of immobilized α-human atrial natriuretic peptide in the affinity purification of antibodies from a polyclonal goat-anti-àhANP serum:Two new approaches using insoluble supports. AC & BR Symposium 1989, Jerusalem (Poster)
  • Th. Kraus, M. Schuller, F. Klee, M. Bredt, A. Mehrabi, E. Hartter, A. Missbichler, Ch. Herfarth: Validation and Differentiation of Endothelin 1/2 and Big Endothelin Immunoreactivity detected in human bile by HPLC. 4th United European Gastroenterology Week (1995), Abstract.
  • G. Hawa, B. Eichinger, S. Friedl. A. Missbichler, FP Armbruster, W. Woloszczuk: Enzymimmunoassay für 25-Hydroxyvitamin D. Poster ÖGLM Steyr 1998
  • A. Missbichler, K. Ettl, N. Schmal, W. Woloszczuk, R. Pacher: Sandwich ELISA zur Bestimmung von pro atrialem natriuretischem Peptid [proANP (1-98)] in Serum. Plasma und Harn. Poster ÖGLM Steyr 1998
  • G. Hawa, B. Eichinger, S. Friedl. A. Missbichler, FP Armbruster, S. Scharla. W. Woloszczuk: Enzyme Binding Protein Assay für 25-Hydroxyvitamin D. Poster IFCC Florenz 1998
  • A. Missbichler, G. Hawa, W. Woloszczuk, E. Hartter, B. STurm, R. Pacher: proANP (1-98), Big Endothelin, BNP 32: Vergleich der Spezifität für die Verlaufsprognose bei Herzinsuffizienz
    Poster ÖGKC 1999, Gmunden
  • A. Missbichler, W. Woloszczuk: Immunoassays for Fragements fo proANP and proBNP. 7th Vienna Shock Forum 11/99; Abstract
  • Albert Missbichler, Petra Moser , Barbara Sturm, Andja Bojic, Richard Pacher: Prognostic Relevance of N-terminal proBNP compared to Big Endothelin in Patients with Advanced Heart Failure. Poster at “Natriuretic Peptides and Vasopeptidase Inhibitors” in Ottawa, 08/2000
  • A. Missbichler, H. Reichl, G. Stegfellner, M. Focke, M. Winter  R. Jarisch: ”Radioextraction Assay for the Quantitative Determination of the Activity of Diamine Oxidase (DAO) in Human Serum” Poster EHRS 2003, Amsterdam
  • Kulichová B, Horna A, Minář J, Missbichler A, Andelová K: “Histamine Intolerance, Diagnosis and Therapy” Poster Vitamins 2006, Pardubice
  • M. Pfisterer, C. Wennemer, K. Fiedler, A. Missbichler: „Diagnosis and Treatment of Histamine Intolerance“ Poster EAACI 2007, Götebor